Antithrombotic and Flow Drag‐Reducing Material for Blood‐Contacting Medical Devices

Blood-contacting medical devices are often associated with shear-induced and contact activation thrombosis. Superhydrophobic materials have shown promise to reduce flow drag forces, but not activation. Here, a strategy of selectively grafting potent anti-thrombin compound on the tips surface microstructures superhydrophobic polytetrafluoroethylene foam, is presented, concurrently achieve reduction anti-thrombosis. This work shows that two approaches – Argon plasma or piranha solution treatment followed by covalent cross-linking can successfully graft drug outer foam provide anti-thrombotic functionality. By avoiding inner regions surface's properties be retained. The functional durability grafted surfaces evaluated strong water jetting, which demonstrates approach withstand substantial fluid shearing approach, although involves stronger compromise capabilities. As proposed selective applied bulk it complemented previously supplying air pressure pores bolster resistance impalement plastron dissolution, allowing material used in high pressures.